A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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Rotary motion of DNA rotors on nanopores. Major row: raw online video with the Cy5 channel of each and every rotor. Center row: corresponding solitary-particle localization outcomes of both of those ends of the DNA rotors. The situation of the current frame is marked as orange and blue dots, as well as the trajectory of The ten frames ahead of The present body is proven as strong traces.
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As being a human being, I contain the biblical assignment to investigate and use all the things in creation for the advantage of my neighbour. I will not encounter any conflict amongst religion and science. Quite the opposite, my faith stimulates me to accomplish science, being open up-minded on the planet.’
Nanofabrication of electrodes with sub-five nm spacing for transport experiments on solitary molecules and metallic clusters
This yielded a breakthrough. In just just a few months, we were in the position to measure transportation by way of an individual solitary-walled carbon nanotube. Based on very low-temperature experiments by a brilliant PhD scholar in my group, Sander Tans (now a valued colleague and professor at Delft University of Technology using an Lively analysis lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes had been authentic quantum wires with extremely prolonged (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic behaviour.
Our investigate ranges from the biophysics of DNA to artificial cells and beyond. Please take a look below on the spectrum of our recent assignments.
Numerous associated developments followed, in which our group proven diverse transistor variants for instance one-electron ceesdekker transistors at home temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled various transistors into small proof-of-principle Digital circuits.
Dynamic ParB–DNA interactions initiate and keep a partition condensate for bacterial chromosome segregation
In 1993, as a young and eager affiliate professor at Delft College of Technologies, I had initially targeted the exploration efforts of my group on measuring the electrical conductance of just one conducting-polymer molecule. Within just two years, we had designed a tool wherein a single wire of a phthalocyaninepolysiloxane polymer was linked amongst two intently spaced metallic nanoelectrodes.
At the moment, we also recognized that it should be feasible to make use of a single semiconducting carbon nanotube to make a transistor — and we established out to really make it. We stretched particular person semiconducting nanotubes throughout metallic electrodes and employed the fundamental silicon substrate for a gate electrode, developing The fundamental three-terminal structure of the discipline-impact transistor (Fig.
Screening pseudotopological and nontopological models for SMC-driven DNA loop extrusion from roadblock-traversal experiments
‘That fears the synthetic mobile, as Portion of the Dutch BaSyC initiative. Craig Venter appeared leading-down in Those people days and determined about 5 hundred genes which might be minimally required for any performing cell. We wish to appear bottom-up: how can we move from a couple molecules to a complete Organic procedure?
Visualization of unstained DNA nanostructures with advanced in-concentrate transmission electron microscopy tactics
2004, discovery of latest physics in translocation of DNA by means of nanopores; first experimental analyze of ions conduction in nanofluidic channels; 1st electrochemistry with person one-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; first electrical docking of microtubules on kinesin-coated nanostructures; initially biophysics characterization in the mechanical properties of double-stranded RNA; and initially single-molecule review of DNA translocation by a restriction-modification enzyme.